ABSTRACT
Portal vein thrombosis(PVT)refers to the formation of thrombus within the portal vein or its branches,the splenic vein,or the superior mesenteric vein. PVT is a common complication after splenectomy in patients with portal hypertension and may lead to liver injury, upper gastrointestinal bleeding,hepatic coma,and even ischemic intestinal necrosis. Therefore,early identification and effective interven-tion of PVT play an important role in reducing the mortality of PVT patients. This article reviews the risk factors for PVT after splenectomy in cirrhotic patients and the treatment of PVT and points out that effective intervention should be performed for PVT as early as possible.
ABSTRACT
Objective To study the effect of folic acid on decreasing level of plasma total homocysteine(tHcy)in patients with sudden sensorineural hearing loss(SSHL) and the optimal dosage of folic acid. Methods Ten randomized controlled trials involving treatment data on 210 patients with SSHL were retrospectively studied.They were divided into seven groups according to the daily dosage of folic acid: group A to group G,0.2 mg,0.4 mg,0.8 mg,2.0 mg,5.0 mg,10.0 mg and 15.0 mg,respectively.Besides oral administration of folic acid,Vitamine B6 and B12were supplemented,and other routine treatment were performed.Fluorescence polarization immunoassay was employed to detect the plasma tHcy before and 3 months after the treatment.And the data of plasma tHcy of 210 patients without SSHL were collected and served as controls.The levels of plasma tHcy were statistically analysed between the SSHL group and control group and among group A to group G. Results The level of plasma tHcy in the SSHL group was significantly higher than that in the control group,(18.07?1.58)?mol/L vs(13.63?1.33) ?mol/L(P0.05). Conclusion The levels of plasma tHcy are significantly increased in SSHL.Folic acid may play an important role in decreasing the levels of tHcy in patients with SSHL,and a dosage of 10 mg/d for oral adminstration is well suggested.